Conversion Ratio of Tryptophan to Niacin in Rats Fed with a Nicotinic Acid-free, Tryptophan-limiting Diet

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Tryptophan and nicotinic acid studies in man.

Recent studies have shown that tryptophan is effective in preventing or curing nicotinic acid deficiency in the rat (l), chick (2), mouse (3), dog (4), pig (5), and rabbit (6). Increased urinary excretion of nicotinic acid or P;S’-methylnicotinamide (NI-Me) after ingestion of tryptophan has been demonstrated in the rat (7), cotton rat (8), horse (8), pig (5), dog (4), calf (9), and human (10, 1...

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Regulation of tryptophan-niacin metabolism in diabetic rats.

The regulation of tryptophan-niacin metabolism was studied in vivo with regard to the activity of liver ƒ¿-amino-ƒÀcarboxymuconate-c-semialdehyde decarboxylase (picolinic carboxylase) using non-diabetic and diabetic rats. Non-diabetic rats and rats with diabetes induced by alloxan were fed on a commercial diet for 80 days, followed by a niacin-free experimental diet for the next 16 days. Protam...

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Effect of Dietary Tryptophan Imbalance upon the Metabolism of Tryptophan and Nicotinic Acid in Man*

Growth of animals receiving diets low in protein and nicotinic acid may be retarded by the addition of corn products (l-4), of certain amino acids (5-9), or of proteins deficient in tryptophan (8-11). This inhibition, which is obtained with diets relatively deficient in tryptophan, can be overcome by the administration of nicotinic acid or of tryptophan (l-11). It has been suggested that this d...

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Urinary excretion of nicotinic acid and N-methyl-nicotinamide by rats fed tryptophan and diets deficient in various B vitamins.

The inability of vitamin Be-deficient rats and mice to convert dietary tryptophan to nicotinic acid and its metabolites has been observed by several workers (l-4). Further, when vitamin Be supplements were given to rats previously deficient in the vitamin, the animals usually recovered the ability to transform tryptophan into nicotinic acid metabolites, although the response was apparently infl...

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Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats

We reported previously that the pellagragenic property of corn protein is not only low l-tryptophan concentration but also the lower conversion percentage of l-tryptophan to nicotinamide; the amino acid composition greatly affected the conversion percentage. The amino acid value of wheat protein is lower than that of rice protein. In the present study, we compare the conversion percentages of l...

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ژورنال

عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry

سال: 1995

ISSN: 0916-8451,1347-6947

DOI: 10.1271/bbb.59.715